With the current foreign relations situation when tactical factors of economic development are almost completely exhausted, and with the amplifying economic pressure from the Western countries, the success and speed of the transition to a non-oil model of economy are inseparably linked with the implementation of the policy of import substitution in the domestic industry. At the same time, the considerable potential of overcoming the adverse effect of external factors and minimizing the constantly arising numerous risks is obviously possible by means of forming integration interactions of multi-scale business, that is, the joint activity of small, medium-sized and large industrial enterprises allowing the participants of the interaction to get additional competitive benefits. The increasingly active state support of industrial projects demands scientific justification of the spheres and scales of the rationality of their import substitution, and also the expediency of using the form of interaction of the industrial enterprises of different scale based on partnership and coordination of interests. The economic role of integration interaction of multi-scale industrial enterprises in developing potential of import substitution of domestic economy is discussed in the paper, along with a system and dynamic model (SDM) of the integration capacity of industrial structures for a scientifically based assessment of the efficiency of combining the resources of multi-scale business for implementing projects of import substitution. Separate optimizing problems are solved through particular models integrated in the SDM; synthesizing these problems allows to estimate the efficiency of realizing the potential for integrating large, medium-sized and small industrial enterprises. Thus, the SDM is a fairly simple and convenient mechanism for carrying out calculations, and can also act as an effective tool for supporting the decision-making, connected with the justification of expediency and a preliminary estimate of the efficiency of merging industrial enterprises.