The article is devoted to the state of the labor market in connection with the dire consequences of the pandemic, the self-isolation regime and limited quarantine. The purpose of the work was to assess the scale and measure of the danger of coronavirus infection for the Russian labor market and the Russian economy, taking into account the related possibilities of digitalization as connected tasks. To investigate the issues that arose, the author engaged a toolkit for the methodology of activity-based comparative studies using statistical indicators of demography and sanitary statistics. Trends and dynamics of employment processes, unemployment rate, demographic difficulties of the country, the impact of the situation in the labor market on certain aspects of digitalization of business processes and the features of work in conditions of remote access to a stationary workplace are considered. The above can be called the obtained reliable research results. The author also raised other special issues of labor relations in the discussion mode. In particular, the doubtfulness of some statistical calculations of the recursive influence of political factors on the behavior of the infection and the consequences of the COVID-19 epidemic using indicators of the incidence, mortality and lethality of this dangerous disease. The possibilities of digitalization of the population are emphasized and it is noted that the current difficult situation for the Russian economy once again presents a favorable chance of overcoming it due to the promising import substitution policy. The directions for further research should be related to the search for the ways to restore the economy, mainly in its real sector, in the context of a limited labor force potential.