The article deals with the research of information-analytical system (IAS) aimed to solve the problem of organization of collective work and support of operative interaction on problems of innovative development of regions. Such components of IAS as a portfolio of methods of estimation of innovative activity, models of quantitative analysis of development of innovative activity, methods of information search (complex activity on gathering, organization, searching, extraction and distribution of information) and also features of offered methods of filling and realization IAS are considered in details.