This paper discusses new forms of digital interaction of economic agents – manufacturing enterprises, non-profit organizations, public authorities and consumers within the framework of business ecosystems based on digital multilateral platforms, the so-called digital business ecosystems. The purpose of this study is to analyze the methodological problems of identifying local and global risk factors caused by changes in consumer preferences and environmental characteristics, and the impact of identified risk factors on the company’s activities when it joins the digital business ecosystem. In the study of the risk phenomenon, we employed the methodology and applied tools of the operational theory of risk management, system economic theory and the theory of socio-economic ecosystems based on digital multilateral platforms as networks of a special kind. It is proved that socio-economic ecosystems, business ecosystems in particular, based on digital multilateral platforms can be considered as fundamentally new socio-technological institutions. We formulated a hypothesis about the existence of several levels of risk management within the digital ecosystem and the emergence of a new tool, user control, in risk management. It is shown that risk management in modern business ecosystems is closely related to the values of a new generation of consumers: safe environment, preservation of biodiversity, social responsibility of enterprises to society, improving the quality of corporate governance, and the so-called ESG-concept (E – Environmental, S – Society, G – Governance). The conducted research may be interesting for enterprises and organizations to use the proposed tools when choosing a strategy for joining the digital business ecosystem.