The purpose of the article is to study the key drivers of digital business transformation in modern conditions that have formed in the national economy, identify and classify drivers in the formation of a digital business transformation strategy, and establish the degree of interest and activity of stakeholders in the formation and use of drivers of digital business transformation. In the context of the development of the digital economy, the issue of digital business transformation is becoming most urgent. Drivers of digital transformation are an important but not so well studied topic that requires special attention. The article describes the goals of digital business transformation and on this basis identifies a list of drivers of digital business transformation as driving forces that contribute to, and often force, the company to implement digital transformation. The identification of the most important and defining drivers of digital business transformation is made on the basis of a study of the corpus of sources in the national electronic resource eLibrary. The authors identified the key stakeholders in the digital business transformation processes based on the diamond model of M. Porter defining competitive advantages of the national economy. This model characterizes stakeholders at the macro, meso, and micro levels. Based on the model, the authors defined the key stakeholders of the digital business transformation as the main parties involved in the digital business transformation: enterprises, their strategies, structure and competition; related and supporting industries; the market providing demand; the industry providing supply; government. For the selected stakeholders, a matrix is constructed that reflects the degree of their interest and activity in the formation and use of drivers of digital business transformation. The article formulates proposals for creating conditions for digital business transformation based on the obtained matrix. The authors concluded that depending on the incentives and causes, a company can have various sets of drivers or driving forces of digital business transformation. In addition, it was established that digital business transformation requires a developed strategy to take the interests of all the parties involved into account. The authors identified the limitations of the research and the directions and ways of further work.