In the digital economy, human capital and knowledge are becoming important drivers of development of organizations. The effectiveness of their application provides companies with sustainable growth and competitiveness. In the Russian Federation, there are a number of studies on the topic of digital economy, digitalization and intellectual capital management. The processes of globalization and development of information and communication technologies oblige domestic enterprises to form competitive advantages, including knowledge and technology. The speed of production and business processes is constantly increasing, the technologies become more accessible, and the need for specialists capable of implementing these technologies grows. The article considers the concept of digital economy and digitalization and defines the role of human resources in this process. Knowledge management has its prerequisites from the side of information technology, personnel management and quality management system. Information technology provides technical capabilities for obtaining, storing, processing and transmitting information, personnel management provides opportunities for selecting the best candidates, their evaluation and motivation, creating an inspiring corporate environment, and a quality management system is intended for linking these elements and making knowledge management processes controllable. Many organizations have not defined the owner and budget of the knowledge management process, so implementation may be formal, and the process itself will not be effective. For effective and efficient implementation of the knowledge management process, we propose a mechanism of personnel management within the quality management system of the organization. International and national standards for quality management systems imply systematic and process approaches to management of the organization's resources, including knowledge management. The result of the study is a knowledge management mechanism for developing the quality management system of the organization. With its help, organizations of different scales can introduce effective knowledge management for their business goals, which will provide them with an increase in intellectual capital and continuous improvements in business processes in accordance with a certain budget.