The article provides a retrospective analysis of the definition of the term «innovation infrastructure». As a result of this analysis, we have formalized two conceptual approaches to defining the innovation infrastructure: the activity and component approaches. These approaches emphasize different immanent characteristics of the term in question. We have substantiated the thesis that the term «innovation infrastructure» requires rethinking and clarification in the context of the digital economy. For instance, there are significant changes that require analysis and formalization in the conditions of deep integration of digital and cloud technologies in the structure and functions of the information subsystem of the innovation infrastructure. We have proposed to introduce the term «information and communication system» as a component of the innovation infrastructure, which identifies its information aspect the most accurately, taking into account the requirements of modern socio-economic realities. The article contains three main characteristics that distinguish the information and communication system from the traditional information subsystem of the innovation infrastructure: 1. Purposefulness and stability of interaction of subjects within information and communication systems. 2. Increasing value of organized information flows and information services as separate elements of the information and communication system. 3. Increasing value of the cognitive structure of public innovation knowledge within regional information and communication systems. The article considers information flows that arise as a result of the interaction between the subjects of innovation activity as a key component of the information and communication system. In our opinion, it is advisable to classify all information flows into 5 main types on the basis of the guiding influence: production, knowledge, service, organizational and managerial, integration-diffuse. To visualize the guiding influences of information flows, we have presented a model of structural organization of information flows within the information and communication system. This model is accompanied by information on its basic elements and principles of functioning. The main tasks aimed at solving the problems of innovative development of information and communication systems are given in conclusion: 1. Strengthening the state support of the innovation infrastructure by increasing the financing of R&D of industrial enterprises. 2. Centralization of the management of regional information and communication systems through establishing special information centers. 3. Increasing the level of development of available technologies for processing and storing data.