The potential of an information system is determined by a combination of the information and economic-mathematical models implemented in it. These models serve as a basis for the information and analytical components. They fulfill various functions: the information component corresponds to the information content and access to data, while the combination of economic-mathematical models of the analytical component determines the intelligence of the data processing. With the development of distributed systems and cloud technologies, the need arises to examine the two components separately. The need to distinguish these two components arises especially acutely in large-scale projects such as the creation of a government infrastructure. Under the conditions of industrial data delivery, when the majority of the participants in an economic activity are acting in the role of producers and consumers of information, standardization of how the data are presented and of the methods of processing them becomes essential. This article handles the two components of an information system as two independent subsystems, the separate stages of creating models are described, and the logic of their interaction in the system is shown. The interrelationship of the components is presented in the form of a reflection of the separate activity logic elements on the information level and further on the program level, as well as the feedback from the applications onto the information and logic of the activity. The description of the components is focused on subject matter experts whose role is growing at the present level of informatization. Most local and simple elements of activity have passed the stage of primary informatization and the task of establishing interaction among the systems and integrating them is becoming urgent. These tasks require a deep understanding of the subject domain in order to embody them in integrational information systems. The training of economic-mathematical and cybernetics specialists is frequently limited by the disciplines of economic-mathematical modeling without proper presentation of these models in information models and applications.