The world economy of 21st ncentury poses new questions and challenges to the players worldwide. The old classical rules of natural resource economy, although stillexisting, have lost its dominating and defining meaning for the development of competitive advantage. Moreover old mechanisms of world economic regulations have recently been proved insufficient and incompetent to protect global markets fr om repetition shock of year 2008. The leading economies have to face new conditions of operating and competing in the era of knowledge economy. Knowledge economy is seen as one strongly based on the intellectual activities of its core players wh ere their intellectual capital and potential become the key resources to build upon. Therefore in regard to the national economic competitiveness the index of national intellectual potential has to be taken into account.